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Emergency physician and astronaut candidate Dr. Shawna Pandya outlines the "RIDGE" framework for space medicine: radiation, isolation and confinement, distance from Earth, gravity, and environment.1:58 Spaceflight-associated neuroocular syndrome (SANS) occurs when microgravity causes upward fluid shifts, leading to increased intracranial pressure, sinus congestion, and structural changes to the eyes.13:06 To mitigate these risks, researchers evaluate intervehicular activity (IVA) and extravehicular activity (EVA) spacesuits using parabolic flights—often called the "vomit comet"—and gravity offset harnesses that simulate lunar or Martian gravity.5:14 These harnesses, previously used at the Canadian Space Agency and now at Florida Tech, allow candidates to practice maneuvers in pressurized suits while offloading up to 83% of their body weight.8:06 While current International Space Station missions rely on resistive and cardiovascular exercise to combat muscle and bone density loss, commercial entities like Above Space Development Corporation and Vast Space are developing spinning, artificial-gravity habitats to address long-term physiological degradation.18:26

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